GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs742132 | 1 | rs59606579 | chr6:25608370 | SCGN | chr6:25652429-25702006:+ | -0.3 | -5.81 | 1.12E-8 | Uric acid levels |
| THCA | cis | rs4888671 | 1 | rs59630213 | chr16:77777030 | NUDT7 | chr16:77756411-77776153:+ | 0.37 | 5.15 | 3.83E-7 | Obesity-related traits |
| THCA | cis | rs2129782 | 1 | rs59645827 | chr8:89436001 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs2416257 | 1 | rs59663729 | chr5:110433789 | TSLP | chr5:110405778-110413722:+ | -0.33 | -4.42 | 1.24E-5 | Eosinophil counts |
| THCA | cis | rs2416257 | 1 | rs59663729 | chr5:110433789 | WDR36 | chr5:110427870-110466201:+ | 0.19 | 3.58 | 0.00038 | Eosinophil counts |
| THCA | cis | rs12435908 | 1 | rs59676254 | chr14:65942840 | LOC645431 | chr14:65877313-65879335:- | -0.59 | -7.8 | 4.04E-14 | Ischemic stroke |
| THCA | cis | rs9914544 | 1 | rs59682951 | chr17:18800766 | FAM18B | chr17:18684582-18710026:+ | -0.42 | -10.43 | 4.53E-23 | Educational attainment (years of education) |
| THCA | cis | rs9914544 | 1 | rs59682951 | chr17:18800766 | FBXW10 | chr17:18647326-18682661:+ | -0.25 | -5.39 | 1.08E-7 | Educational attainment (years of education) |
| THCA | cis | rs12435908 | 1 | rs59685862 | chr14:66080130 | LOC645431 | chr14:65877313-65879335:- | -0.62 | -7.96 | 1.24E-14 | Ischemic stroke |
| THCA | cis | rs11825709 | 1 | rs59689949 | chr11:93706695 | HEPHL1 | chr11:93754378-93847374:+ | 0.49 | 3.95 | 8.96E-5 | Obesity-related traits |
| THCA | cis | rs11671653 | 1 | rs59715646 | chr19:10839447 | SLC44A2 | chr19:10713121-10755234:+ | 0.3 | 3.4 | 0.000743 | LDL cholesterol |
| THCA | cis | rs7714584 | 1 | rs59715748 | chr5:150189287 | LOC134466 | chr5:150310000-150326146:- | 0.45 | 5.75 | 1.55E-8 | Crohn's disease |
| THCA | cis | rs7714584 | 1 | rs59715748 | chr5:150189287 | ZNF300 | chr5:150273964-150284391:- | 0.18 | 3.71 | 0.000236 | Crohn's disease |
| THCA | cis | rs12748152 | 1 | rs59715866 | chr1:27079176 | ZDHHC18 | chr1:27153201-27182207:+ | 0.8 | 8.63 | 9.37E-17 | HDL cholesterol;Triglycerides;LDL cholesterol |
| THCA | cis | rs2129782 | 1 | rs59725465 | chr8:89410497 | MMP16 | chr8:89049462-89339717:- | 0.31 | 5.04 | 6.5E-7 | Electrodermal activity |